Is Hydroxypinacolone Retinoate safe during pregnancy?
A newer retinoid ester (Granactive Retinoid). Treat like other retinoids: not recommended in pregnancy.
PregnancyNot recommended
BreastfeedingUse with care
EvidenceLimited
What the sources say
Hydroxypinacolone retinoate is a retinoid ester used in OTC anti-aging products. There are no pregnancy studies. ACOG advises avoiding topical retinoids, including OTC forms, during pregnancy, and AAD lists retinoids as not for use in pregnancy, so the class advice applies. For breastfeeding, LactMed considers topical retinoids poorly absorbed and low risk; keep off the nipple area and away from the baby's skin.
Common alternatives
Also listed as
dimethyl isosorbide (and) hydroxypinacolone retinoate, granactive, granactive retinoid, hpr, retinoid ester
Sources
- ACOG: Skin Conditions During Pregnancy
- AAD: Dermatologist-approved pregnancy skin care
- NIH LactMed: Tretinoin - Drugs and Lactation Database (LactMed)
Last reviewed . This is general information, not medical advice. Ask your doctor or midwife about your own situation.