Is Peptides safe during pregnancy?
Anti-aging signal peptides are a commonly suggested pregnancy-friendly swap for retinoids.
What the sources say
A 2025 review of skin care and sunscreen for pregnant and lactating women mentions peptides (with hyaluronic acid) as anti-aging ingredients used in formulations for this group. No pregnancy concerns were identified, but pregnancy-specific studies are lacking, so evidence is rated limited. Check that a peptide serum doesn't also contain retinol.
Also listed as
acetyl hexapeptide-3, acetyl hexapeptide-8, argireline, copper peptide, copper tripeptide-1, ghk-cu, matrixyl, oligopeptide, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5
Sources
Last reviewed . This is general information, not medical advice. Ask your doctor or midwife about your own situation.